Nanoceria Can Inhibit the Reproduction of Transmissible Gastroenteritis Virus: Consideration for Use to Prevent and Treat Coronavirus Disease
نویسندگان
چکیده
Nanoceria (cerium dioxide nanoparticles, CeO2) has a broad range of biological properties including antiviral activity. The hypothesis was that nanoceria can efficacy against coronavirus (coronavirus porcine transmissible gastroenteritis) and potentially target SARS-CoV-2. Transmissible gastroenteritis (TGEV) is the etiologic agent (PTG), highly contagious pig intestinal disease. aim study to determine activity CeO2 nanoparticles on model – TGEV. Methods. We used pathogenic virus strain D52-5 (BRE79), evaluated experimental (transmissible virus) in transplantable line embryonic kidney cells (PEK) culture. Results. criterion for evaluating inhibitory drugs different vitro systems selectivity index (SI) reduction infectious titer by 1.5–2.0 lgTCD50. effectively inhibited reproduction with SI 83.3.
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ژورنال
عنوان ژورنال: Mìkrobìologì?nij žurnal
سال: 2021
ISSN: ['2616-9258', '1028-0987']
DOI: https://doi.org/10.15407/microbiolj83.05.067